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Benefits of timsTOF
PASEF enables MS/MS acquisition at >100 Hz, making high-throughput measurements using short gradients possible while maintaining deep proteome coverage or high protein depth measurements in less time.
It identifies more near-isobaric peptides and post-translationally modified (PTMs) peptides per unit time. PTM-positional isomers can also be quantified.
CCS-Aware analysis software increases the confidence of identifications and quantitation, while increasing data completeness.
The time-focusing benefit of dual-TIMS funnel technology increases sensitivity thereby allowing for loading of lower sample amounts and simpler sample preparation techniques.
The orthogonal geometry of the inlet glass capillary to the axis of the mass analyzer combined with dual-TIMS funnel technology, greatly increases robustness, allowing for sustained MS performance over large sample cohorts, maximizing instrument uptime.
Open data format easily allows timsTOF data to be used in custom developed bioinformatics solutions.
Analyze isomeric compounds
High-confidence forensic screening
Characterize metabolites and secondary metabolites
True Isotopic Pattern or TIPTM
Food and environmental research
