Screen, identify & semi-quantify Known & Unknown targets with much more confidence
Identified Polar, a nonpolar compound in a single run
>12 min Run & Analysis time (Sample to Report)
Curated Library & Methods for over 6000+ Toxicology relevant compounds & their metabolites
New compound can be added in few clicks
UHPLC combined with true MSn and comprehensive Drug Libraries
Bruker Daltonics the leader in Mass Spectrometry Solutions Explaining TIMS within timsTOF Technology
Protein Interaction Network
Post Translational Modification
Single Cell Protein
An instrument for every need:
Integrated benchtop system for Research Labs
For Core Labs and High Sample Throughput
nCounter Life Science Assays:
Expandable with Additional Prep Station:
PROSIGNA optional add-on:
Runs Per Day:
Throughput (Lanes Per Day):
Hands on Time:
Reaction Volume Required:
Linear Dynamic Range:
Up to 35 µl
6 x10* total count
12 lanes/6 hours
Up to 30 µl
7 x10* total count
12 lanes/2.5 hours
UHR QTOF mass spectrometer with Full Scan MS and broadband CID (bbCID) MS/MS methods
An Elute UHPLC system, with Bruker columns, mobile phases, and QC standard
TASQ screening and quantitation software for rapid data processing, including ready methods for multi-target screening
The high-quality and robust TargetScreener database including more than 3000 entries relevant for food safety, environmental protection, and toxicology research screening
UHPLC combined with true MSn and comprehensive drug libraries
The IR Biotyper and Bruker’s MALDI Biotyper can now be combined into a single seamless workflow. Data from the MALDI Biotyper® – which uses MALDI-TOF MS to identify microorganisms to species or genus level within a few minutes – can be imported into the IR Biotyper software, and once analyzed, the entire set of results can be exported to the laboratory’s LIMS in CSV format.
Simple Workflows for Rapid Processing
Analysis by DART-MS relies on a gas-phase ionization mechanism. Initial generation of the ionizing species is by a corona discharge with helium or nitrogen which delivers excited gas atoms that, upon their release into the atmosphere, initiates a cascade of gas-phase reactions. This results in reagent ions created from atmospheric water or (solvent) vapor in the vicinity of the surface subject to analysis where they affect a chemical ionization process. DART ionization processes can generate positive or negative ions, predominantly even-electron specie
Comprehensive Solutions for Every Workflow
Trapped Ion Mobility Spectrometry (TIMS) is a separation technique in the gas phase, which resolves sample complexity with an added dimension of separation in addition to HPLC and mass spectrometry, increasing peak capacity and confidence in the compound characterization. TIMS device also serves to accumulate and concentrate ions of a given mass and mobility, enabling a unique increase in sensitivity and speed along with the additional dimension of separation.
In this technique, ions are propelled through the TIMS tunnel by a gas flow. An electrical field controls each ion from moving beyond a position defined by the ion’s mobility, where the push it experiences from the gas flow matches the force of the electrical field. Ramping down the electrical field allows selectively releasing ions from the TIMS tunnel according to their mobility. By incorporating a TIMS device at the front of a quadrupole time-of-flight (QTOF) mass spectrometer, ions can be accumulated for a specific amount of time before being released for MS analysis.
Using the PASEF® method, peptide ions are separated using TIMS, eluted (~ 100 ms), and detected in the QTOF, generating the TIMS MS heat map. In the PASEF® method, the same TIMS separation is used with the quadrupole isolating a certain ion species during its elution and immediately shifting to the next precursor. Parent and fragment spectra are aligned by mobility values. With PASEF® technology >100 Hz sequencing speed can be achieved, and the MS/MS spectra quality of low abundant peptides can be increased by selecting them several times.
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