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Workflow of the System
The highly unique TIMS design enables unmatched duty cycle (up to 100%), significant improvement in IMS resolution (R>200), unprecedented collisional cross section (CCS) reproducibility and high sensitivity.
timsTOF combines high ion mobility resolution with ultra-high resolution QTOF technology for optimal performance. imeXTM technology further boosts the functionality by making ion mobility resolution an adjustable parameter.
Investigating samples in imeX survey mode can lead to mobility-resolved full scans, and then extending workflow with a detailed examination of selected compounds and precise collisional cross sections (CCS). Increased ion mobility resolution up to 200 for unique insights into samples can be acheived in imeX ultra mode.
Data-independent acquisition dia-PASEF is both more sensitive and selective than traditional DIA approaches as it applies the PASEF principle to combine the advantages of DIA with the inherent ion efficiency of PASEF. Over the entire liquid chromatography-mass spectrometry (LC-TIMS-MS)/MS dia-PASEF run, a perfect data cuboid is created containing m/z, ion mobility (CCS), retention time and intensity. TIMS separation increases selectivity, excludes singly charged precursors from fragmentation and cleans up the sample by concentrating signals from noise. Making use of the correlation of molecular weight and CCS coded information from the dual-TIMS funnel, dia-PASEF enables highly confident identification.
The timsTOF fleX combines 4D-Omics with MALDI Imaging technology, including smartbeam 3D laser optics to be a fast measurement all in one platform.
It is a dual source instrument ideal for SpatialOMx®. It conducts robust ESI measurements and spatially resolves a wide range of molecules directly from tissue using one platform.
During operation, software activation of the smartbeam 3D laser is the only change in the source region to change from ESI to MALDI in seconds.
timsTOF Flex MALDI 2 provides post ionization technique which reduces ion suppression effects and improves sensitivity by orders of magnitude. After the initial MALDI process, a second laser, sitting parallel to the sample surface, fires into the evolving plume and post-ionizes neutral (mainly matrix) molecules. A charge transfer from post-ionized matrix molecules to neutral analyte molecules leads to an amazing sensitivity gain for many analytes.
MALDI-2 post-ionization compensates the lower sample amount per pixel, making even the finest molecular distributions visible. Combining MALDI-2 post-ionization with microGRID enabled high spatial resolution opens the field for the analysis of the smallest unit of eukaryotic life - single cells.
TimsTOF MALDI Pharmapulse (MPP) uses a dual MALDI / ESI ion source with industry-leading 10 kHz smartbeam™ 3D laser which enable uHTS compatible speed and throughput. It supports rapid gas-phase separation of isobars, and even isomers, by exploiting the molecular collisional cross-section. This, in combination with routine 50,000 mass resolution in QTOF-MS detection facilitates revolutionary levels of assay specificity. It features the extreme speed and proven robustness of MALDI in the essence of tims technology.
It has an automation interface which supports HTS application of drug discovery. It has MPP 2023 which enables seamless transfer of data and results to downstream analysis software.
Faster separation of isobars and isomers
It is capable of separating isobars and even isomers on a timescale of ≤ 1 sec per separation cycle.
Data quality delivered at uncompromised HTS speed
Readout of a 1536 formatted sample plate in high-resolution MS or MS/MS mode takes less than 10 minutes
A simple, single-use wire mesh card for transferring samples powders and liquids for DART-MS analysis. OpenSpot® sample cards are an easy-to-use, simple solution for sampling powders and liquids for DART-MS using the DART-OS interface. Each wire mesh card accepts and retains a single sample.
QuickStrip™ sample cards for DART JumpShot® are an easy-to-use, simple solution for the automatic sampling of powders and liquids for DART-MS. Each card has 12 equally spaced sample positions. To use, simply spot samples onto the wire mesh screen, into each space, as indicated. Include standards for quantitation if needed. Then load the whole card into the DART interface.
QuickStrip™ HTS sample cards for DART JumpShot® are designed for customers looking to use auto-pipettors and robotic sample pipetting systems to implement high throughput DART-MS.Touse, position a full 96 or 384 well plate on the sample stage of a chosen pipetting station. Mount the QuickStrip™ HTS in its purpose-built metal frame on top of the plate to deposit an accurate volume of sample in each discreet screen position.
DIP-it® Samplers provide a convenient means to prepare and position samples for DART analysis. Available in 96-well plate format, sampling is simple: just dip the tip and present for analysis in seconds. No preparation required. The tips can be used with both liquids and solids, and are compatible with a variety of 100 microliter volume pipettors. Ionization occurs in seconds.
Perfect for use with DART-OS and DART JumpShot®.
Formed from SPME fibers, SPE-it tips deliver a SPME device in the form of an easy-to-handle micropipette tip. Specifically designed for use with the integrated DART SPE-it™ kit, they permit the isolation of analytes from aqueous solutions and direct analysis by DART-MS. Perfect for use with DART-OS and DART JumpShot® for automated analyses.
DART-OS enables a very simple workflow, for a wide range of sample types
Start the system - switch on the source and start the VAPUR pump
Spot or dose the sample onto an OpenSpot® sample card in the clearly marked area
Slot the card into the system to guide your sample into exactly the right position for successful analysis
Scan – the system will apply transmission mode DART passing a heated carrier gas through the sample
Remove the card and discard