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ultrafleXtreme

MALDI-TOF/TOF MS

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ultrafleXtreme

Fast and direct results for efficient research

High content data
Full MS/MS data sets can be acquired with up to 1000 Hz laser repetition rate from low fmollevels within seconds.
Confidence
Dedicated software analyzes and visualizes the high content data automatically, generating results with high confidence identifications.
Flexible
The well-established proprietary smartbeam-II laser provides unprecedented analytical and matrix flexibility in diverse workflows.
Top-Down protein sequencing
Top-Down protein sequencing
Advanced Peptide and Protein analysis
Advanced Peptide and Protein analysis
Oligo QC at unparalleled pace
Oligo QC at unparalleled pace
Polymer Analysis
Polymer Analysis
MALDI Imaging
MALDI Imaging

Applications

Redefine MALDI-TOF/TOF performance

Smartbeam-II laser

Smartbeam-II laser

Smartbeam-II laser enables high data acquisition speed in both MS and MS/MS at full systems performance.

Broadband

Broadband

Broadband mass resolving power.

Flash Detector Combined

Flash Detector Combined

The Flash Detector combined with a 5 GS/s 10-bit digitizer and latest advances in electronics provide mass resolving power up to 40,000 and 1 ppm mass accuracy for highest confidence.

IR-Laser Based Self-Cleaning

IR-Laser Based Self-Cleaning

The IR-laser based self-cleaning ion source ensures robust, long-term highest-performance operation

Full MS/MS Data Sets

Full MS/MS Data Sets

Full MS/MS data sets can be acquired with up to 1000 Hz laser repetition rate from low fmol levels within seconds.

Measure Protein Assays

Measure Protein Assays

Measure protein assays with 1-2% CV

Non-Biased Polymer Analysis

Non-Biased Polymer Analysis

Non-biased polymer analysis yielding true polymer distributions with a single click using Poly Tools Software

Conquer

Conquer

Conquer peptide and protein samples too difficult for ESI

LC-MALDI

LC-MALDI

LC-MALDI – the solution for your difficult challenges with optional LC-MALDI spotter - spotOn®

ultrafleXtreme

ultrafleXtreme

MALDI-TOF/TOF MS

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Workflow of the System

Related Videos

The highly unique TIMS design enables unmatched duty cycle (up to 100%), significant improvement in IMS resolution (R>200), unprecedented collisional cross section (CCS) reproducibility and high sensitivity.
timsTOF combines high ion mobility resolution with ultra-high resolution QTOF technology for optimal performance. imeXTM technology further boosts the functionality by making ion mobility resolution an adjustable parameter.
Investigating samples in imeX survey mode can lead to mobility-resolved full scans, and then extending workflow with a detailed examination of selected compounds and precise collisional cross sections (CCS). Increased ion mobility resolution up to 200 for unique insights into samples can be acheived in imeX ultra mode.

Data-independent acquisition dia-PASEF is both more sensitive and selective than traditional DIA approaches as it applies the PASEF principle to combine the advantages of DIA with the inherent ion efficiency of PASEF. Over the entire liquid chromatography-mass spectrometry (LC-TIMS-MS)/MS dia-PASEF run, a perfect data cuboid is created containing m/z, ion mobility (CCS), retention time and intensity. TIMS separation increases selectivity, excludes singly charged precursors from fragmentation and cleans up the sample by concentrating signals  from noise. Making use of the correlation of molecular weight and CCS coded information from the dual-TIMS funnel, dia-PASEF enables highly confident identification.

The timsTOF fleX combines 4D-Omics with MALDI Imaging technology, including smartbeam 3D laser optics to be a fast measurement all in one platform. 
It is a dual source instrument ideal for SpatialOMx®. It conducts robust ESI measurements and spatially resolves a wide range of molecules directly from tissue using one platform. 
During operation, software activation of the smartbeam 3D laser is the only change in the source region to change from ESI to MALDI in seconds.

timsTOF Flex MALDI 2 provides post ionization technique which reduces ion suppression effects and improves sensitivity by orders of magnitude. After the initial MALDI process, a second laser, sitting parallel to the sample surface, fires into the evolving plume and post-ionizes neutral (mainly matrix) molecules. A charge transfer from post-ionized matrix molecules to neutral analyte molecules leads to an amazing sensitivity gain for many analytes.

MALDI-2 post-ionization compensates the lower sample amount per pixel, making even the finest molecular distributions visible. Combining MALDI-2 post-ionization with microGRID enabled high spatial resolution opens the field for the analysis of the smallest unit of eukaryotic life - single cells.

TimsTOF MALDI Pharmapulse (MPP) uses a dual MALDI / ESI ion source with industry-leading 10 kHz smartbeam™ 3D laser which enable uHTS compatible speed and throughput. It supports rapid gas-phase separation of isobars, and even isomers, by exploiting the molecular collisional cross-section. This, in combination with routine 50,000 mass resolution in QTOF-MS detection facilitates revolutionary levels of assay specificity. It features the extreme speed and proven robustness of MALDI in the essence of tims technology.

It has an automation interface which supports HTS application of drug discovery. It has MPP 2023 which enables seamless transfer of data and results to downstream analysis software.

Faster separation of isobars and isomers
It is capable of separating isobars and even isomers on a timescale of ≤ 1 sec per separation cycle.

Data quality delivered at uncompromised HTS speed
Readout of a 1536 formatted sample plate in high-resolution MS or MS/MS mode takes less than 10 minutes

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DART-OS enables a very simple workflow, for a wide range of sample types