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rapifleX® MALDI Tissuetyper

MALDI-TOF/TOF MS

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rapifleX® MALDI Tissuetyper

Novel ion source design for robust day-to-day operation

Easy Access
Easy access to self-aligning ion lenses when cleaning is in fact needed.
No Tools Needed
No tools are needed to extract the whole first lens package which then can be rinsed with Ethanol, dried and re-inserted
Wizard Driven
Wizard driven user-friendly set up of new experiments
True 64-bit application
True 64-bit application allows efficient handling of megapixel datasets
Direct Access
Direct access to single mass spectra
Co-register and Super-Impose Virtual Microscopic Slides
Co-register and super-impose virtual microscopic slides at full resolution for detailed histological annotation.
Proteomics
Proteomics
Lipidomics
Lipidomics
Clinical Research
Clinical Research
Drug Discovery
Drug Discovery

Applications

True Pixel MALDI Imaging and pixel-to-pixel reproducibility.

Smartbeam3D

Smartbeam3D

Smartbeam3D laser for better sensitivity

Novel ion source design

Novel ion source design

Novel ion source design for increased robustness and maximized uptime.

Ease-of-use Workflow

Ease-of-use Workflow

Assisted with the new ease-of-use workflow

Integrated Software Solutions

Integrated Software Solutions

Integrated software solutions - imaging and statistical analysis

rapifleX® MALDI Tissuetyper

rapifleX® MALDI Tissuetyper

MALDI-TOF/TOF MS

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Workflow of the System

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The speed of the rapifleX® Tissuetyper® allows for fast acquisition of images and SCiLS™ Lab solution seamlessly allows for classification of the data sets, enabling tissue typing at minimal time. Tissue micro arrays can be analyzed very rapidly. The soft smartbeam 3D laser effectively ionizes the analytes but does not harm the tissue, in fact histological staining is possible after the acquisition of the MALDI data set.

The highly unique TIMS design enables unmatched duty cycle (up to 100%), significant improvement in IMS resolution (R>200), unprecedented collisional cross section (CCS) reproducibility and high sensitivity.
timsTOF combines high ion mobility resolution with ultra-high resolution QTOF technology for optimal performance. imeXTM technology further boosts the functionality by making ion mobility resolution an adjustable parameter.
Investigating samples in imeX survey mode can lead to mobility-resolved full scans, and then extending workflow with a detailed examination of selected compounds and precise collisional cross sections (CCS). Increased ion mobility resolution up to 200 for unique insights into samples can be acheived in imeX ultra mode.

Data-independent acquisition dia-PASEF is both more sensitive and selective than traditional DIA approaches as it applies the PASEF principle to combine the advantages of DIA with the inherent ion efficiency of PASEF. Over the entire liquid chromatography-mass spectrometry (LC-TIMS-MS)/MS dia-PASEF run, a perfect data cuboid is created containing m/z, ion mobility (CCS), retention time and intensity. TIMS separation increases selectivity, excludes singly charged precursors from fragmentation and cleans up the sample by concentrating signals  from noise. Making use of the correlation of molecular weight and CCS coded information from the dual-TIMS funnel, dia-PASEF enables highly confident identification.

The timsTOF fleX combines 4D-Omics with MALDI Imaging technology, including smartbeam 3D laser optics to be a fast measurement all in one platform. 
It is a dual source instrument ideal for SpatialOMx®. It conducts robust ESI measurements and spatially resolves a wide range of molecules directly from tissue using one platform. 
During operation, software activation of the smartbeam 3D laser is the only change in the source region to change from ESI to MALDI in seconds.

timsTOF Flex MALDI 2 provides post ionization technique which reduces ion suppression effects and improves sensitivity by orders of magnitude. After the initial MALDI process, a second laser, sitting parallel to the sample surface, fires into the evolving plume and post-ionizes neutral (mainly matrix) molecules. A charge transfer from post-ionized matrix molecules to neutral analyte molecules leads to an amazing sensitivity gain for many analytes.

MALDI-2 post-ionization compensates the lower sample amount per pixel, making even the finest molecular distributions visible. Combining MALDI-2 post-ionization with microGRID enabled high spatial resolution opens the field for the analysis of the smallest unit of eukaryotic life - single cells.

TimsTOF MALDI Pharmapulse (MPP) uses a dual MALDI / ESI ion source with industry-leading 10 kHz smartbeam™ 3D laser which enable uHTS compatible speed and throughput. It supports rapid gas-phase separation of isobars, and even isomers, by exploiting the molecular collisional cross-section. This, in combination with routine 50,000 mass resolution in QTOF-MS detection facilitates revolutionary levels of assay specificity. It features the extreme speed and proven robustness of MALDI in the essence of tims technology.

It has an automation interface which supports HTS application of drug discovery. It has MPP 2023 which enables seamless transfer of data and results to downstream analysis software.

Faster separation of isobars and isomers
It is capable of separating isobars and even isomers on a timescale of ≤ 1 sec per separation cycle.

Data quality delivered at uncompromised HTS speed
Readout of a 1536 formatted sample plate in high-resolution MS or MS/MS mode takes less than 10 minutes

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