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Benefits of NIMBUS Select

Liquid Biopsy

Studies show there is a specific size discrepancy between the cell free DNA that comes off of a tumour versus the cell free DNA that comes off of healthy cells. Using Ranger® Technology gel-size selection, the LightBench® may be used to enhance cfDNA detection. LightBench® using Ranger® Technology can provide a better outcome for patients by reducing sequencing noise to combat false-positive results. New research has shown that the cost of determining genetic conditions through sequencing can be improved through gel size selection that looks to recover cfDNA from non-normal tissues while excluding that from healthy, normal cells.

NGS library QC

Powered by Ranger Technology, the LightBench® allows you to automate the process of electrophoresis, supporting optimisation of your research NGS workflows by enabling you to sequence more of the DNA you really care in record time. The core size selection LightBench® functionality is complemented by the ability to perform fragment length analysis and fluorescence assays for full NGS quality control assessment

Small Nucleic Acid Work

The operating principle behind Ranger® Technology was developed with the intent of recovering small nucleic acids whilst confidently rejecting adaptermers that were close in size to the target. Work with microRNA-SEQ experiments greatly benefits from size selection, which can be accurately conducted at any scale with Ranger® Technology.

Applications

Assays/Consumables/Software

The only choice for cost-effective full automation of electrophoretic analysis

CfDNA analysis

Studies show there is a specific size discrepancy between the cell free DNA that comes off of a tumour versus the cell free DNA that comes off of healthy cells. Using Ranger® Technology gel-size selection, the LightBench® can be used to enhance cfDNA detection.

High recovery yield and reproducibility

Industry-leading average recovery yield of >70% and >97% reproducibility

Reduce Cost

Reduce overall spend on BCT ~10x fold by using of EDTA blood collection tubes (BCTs) instead of Streck BCTs.

Uniform and precise results

Independent lane voltage automatically to give a more uniform result & 30mm gel results in a distinctive sharp cut-off in size selection for a more precise result

High Throughput

Up to 96 DNA samples may be processed in two hours, and up to 384 electropherograms may be created in a single run

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Workflow of the System

Related Videos

Yourgene Health have implemented Ranger® Technology for electrophoresis and size selection to the NIMBUS Select workstation. The NIMBUS Select automates the entire process of electrophoresis for either size selection or fragment length analysis, and is of particular value for high-throughput laboratories.

The highly unique TIMS design enables unmatched duty cycle (up to 100%), significant improvement in IMS resolution (R>200), unprecedented collisional cross section (CCS) reproducibility and high sensitivity.
timsTOF combines high ion mobility resolution with ultra-high resolution QTOF technology for optimal performance. imeXTM technology further boosts the functionality by making ion mobility resolution an adjustable parameter.
Investigating samples in imeX survey mode can lead to mobility-resolved full scans, and then extending workflow with a detailed examination of selected compounds and precise collisional cross sections (CCS). Increased ion mobility resolution up to 200 for unique insights into samples can be acheived in imeX ultra mode.

Data-independent acquisition dia-PASEF is both more sensitive and selective than traditional DIA approaches as it applies the PASEF principle to combine the advantages of DIA with the inherent ion efficiency of PASEF. Over the entire liquid chromatography-mass spectrometry (LC-TIMS-MS)/MS dia-PASEF run, a perfect data cuboid is created containing m/z, ion mobility (CCS), retention time and intensity. TIMS separation increases selectivity, excludes singly charged precursors from fragmentation and cleans up the sample by concentrating signals from noise. Making use of the correlation of molecular weight and CCS coded information from the dual-TIMS funnel, dia-PASEF enables highly confident identification.

The timsTOF fleX combines 4D-Omics with MALDI Imaging technology, including smartbeam 3D laser optics to be a fast measurement all in one platform.
It is a dual source instrument ideal for SpatialOMx®. It conducts robust ESI measurements and spatially resolves a wide range of molecules directly from tissue using one platform.
During operation, software activation of the smartbeam 3D laser is the only change in the source region to change from ESI to MALDI in seconds.

timsTOF Flex MALDI 2 provides post ionization technique which reduces ion suppression effects and improves sensitivity by orders of magnitude. After the initial MALDI process, a second laser, sitting parallel to the sample surface, fires into the evolving plume and post-ionizes neutral (mainly matrix) molecules. A charge transfer from post-ionized matrix molecules to neutral analyte molecules leads to an amazing sensitivity gain for many analytes.

MALDI-2 post-ionization compensates the lower sample amount per pixel, making even the finest molecular distributions visible. Combining MALDI-2 post-ionization with microGRID enabled high spatial resolution opens the field for the analysis of the smallest unit of eukaryotic life - single cells.

TimsTOF MALDI Pharmapulse (MPP) uses a dual MALDI / ESI ion source with industry-leading 10 kHz smartbeam™ 3D laser which enable uHTS compatible speed and throughput. It supports rapid gas-phase separation of isobars, and even isomers, by exploiting the molecular collisional cross-section. This, in combination with routine 50,000 mass resolution in QTOF-MS detection facilitates revolutionary levels of assay specificity. It features the extreme speed and proven robustness of MALDI in the essence of tims technology.

It has an automation interface which supports HTS application of drug discovery. It has MPP 2023 which enables seamless transfer of data and results to downstream analysis software.

Faster separation of isobars and isomers
It is capable of separating isobars and even isomers on a timescale of ≤ 1 sec per separation cycle.

Data quality delivered at uncompromised HTS speed
Readout of a 1536 formatted sample plate in high-resolution MS or MS/MS mode takes less than 10 minutes