CleanPlex® ACE2 & TMPRSS2 Panel

CleanPlex® ACE2 & TMPRSS2 Panel

For Research Use Only. Not for use in diagnostic procedures.

  • The CleanPlex® ACE2 & TMPRSS2 Panel is a multiplex PCR-based targeted sequencing assay designed to examine two genes associated with COVID-19 susceptibility.

  • Research has shown that the SARS-CoV-2 virus is internalized by the binding of its S protein to the host ACE2 with the help of TMPRSS2. The binding affinity of ACE2, along with ACE2 and TMPRSS2 expression levels, are major determinants of SARS-CoV-2 replication rate and disease severity.

  • This panel targets all exonic and promoter regions of the two genes, and more than 70 expertly curated expression quantitative trait loci (eQTL), shown to regulate gene expression.

  • The CleanPlex ACE2 & TMPRSS2 panel facilitates further investigations in host genome mutations related to the ACE2 binding affinity and expression of ACE2 and TMPRSS2, which could provide additional insights into an individual’s viral susceptibility and their disease course.

Targeted Sequencing of ACE2 and TMPRSS2 for COVID-19 Susceptibility

Superb Performance with Low DNA Input

Prepare high-quality NGS libraries with excellent coverage uniformity and on-target performance to enable efficient use of sequencing reads and reduce costs

Fast, Streamlined Workflow

Generate libraries for Illumina® platforms in just 3 hours using a simple, three-step protocol

Curated Content and Comprehensive Data

Interrogates entire ACE2 & TMPRSS2 coding and promotor regions plus curated 70+ eQTL targets

Specifications

SKU

Description

Pack Size

SKU
Description
Pack Size

916120

CleanPlex ACE2 & TMPRSS2 Panel

8 reactions

SKU
Description
Pack Size

916121

CleanPlex ACE2 & TMPRSS2 Panel

96 reactions

SKU
Description
Pack Size

716006

CleanPlex Dual-Indexed PCR Primers for Illumina® Set A

96 indexes, 96 reactions

SKU
Description
Pack Size

716018

CleanPlex Dual-Indexed PCR Primers for Illumina® Set B

96 indexes, 96 reactions

ACE2 & TMPRSS2 Panel
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