Gene expression profiling includes detection of genetic variants that increases your risk for certain health conditions. It can provide diagnostic and prognostic information that aids in difficult clinical decision making. The technique chosen depends on both the clinical question and the predictive value of the available tests.
Only one gene is not responsible for a particular disease. Disease sometimes is a result of set of genes showing expression or suppressing the expression. For the complete study from discovery to translation, gene expression analysis is mandatory.
Genomic profiling in India has evolved in leaps and bounds in the past decade. Currently, there exist DNA-based tests that address multiple concerns in healthcare, from disease prevention to molecular diagnosis.
We provide all kind of genomics services and kits that involves the technologies like sanger sequencing, qPCR, microarray, next generation sequencing and nCounter digital direct detection technology.
Gene Expression Analysis
Diagnosis of disease or a type of disease.
Determination of the cause of a disease.
Determination of treatment options for a disease.
Tracking the prognosis of disease or cancer
Find the risk of getting a certain disease that can possibly be prevented.
Importance of Gene Expression Analysis
Applications by Market Segment
Clinical
Biopharma
Applied Market
Research
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Identification of disease/ biomarker
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Identification of micro-organisms/ viruses
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Biomarker discovery
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Drug/ vaccine development and validation
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Treatment efficiency
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Microbial identification
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Surveillance of viruses or microbes
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Novel gene identification
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Determination of disease progression
Technologies complement each other
Nowadays, many technologies are available for the genes expression analysis. However selecting appropriate technology is essential and depending on the number of genes you want to analyze, known or unknown gene detection.
Parameters
Sanger
qPCR
nCounter
Microarray
NGS
Genes per reaction
Known and unknown gene detection
Data analysis
Cost
1 Gene
Up to 4 Genes
30 - 800 Genes
Whole Genome
Targeted or Whole Transcriptome
Only for known Genes
Only for known Genes
Only for known Genes
Only for known Genes
For known and unknown Genes
Easy
Easy
Easy
Difficult
Difficult
Low
Low
Mid-Range
High
High
Applications of Gene Expression Analysis
Prediction of Disease
Diagnosis
Prognosis
Treatment
Discovery
At a genomic level gene expression for disease can be seen but it is maybe suppressed at a phenotypic level. Individuals may suffer from a particular disease in future.
Diagnosis of the disease can be done by biomarker identification.
Certain set of genes are expressed in particular pathways. It is useful in determination of disease progression.
Some biomarkers are targeted by either shutting them down or blocking it. By Gene Expression Analysis we can determine the treatment efficiency.
Biomarker discovery is essential for the identification of a particular disease. Or novel gene identification can be done using NGS technologies.
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Primers and probe designing
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Gene expression analysis services
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Microbial identification by 16 rRNA sequencing
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Whole transcriptome sequencing
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Targeted mRNA/miRNA sequencing
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Direct digital quantification of mRNA/ miRNA
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Metagenomics
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