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nCounter® Host Response Panel
Prosigna Score / ROR Score:
The ROR Score has been validated to predict the risk of recurrence of disease in ER+ breast cancer after surgery and treatment with 5 years of endocrine therapy. The ROR score depends upon the biology of the intrinsic subtypes, the proliferation score of the tumor, and the tumor size as shown in the equation below:
ROR = aRLumA + bRLumB + cRHer2 + dRBasal + eP + fT
Each of the R variables in the equation above indicate the Pearson correlation coefficient of the PAM50 expression profile for the tumor compared to each of the prototypical centroids for the intrinsic subtypes shown in the heatmap below. P is the proliferation score, which is the average gene expression profile of genes associated with cell-cycle progression and T is the tumor stage.
Figure: Heatmap of PAM50 genes by subtype. Red is higher expression and green is lower expression
The nCounter® Host Response Panel helps researchers study the phases and progression of infection across the major components of the human or mouse host response with pathogen-agnostic content optimized for blood but suitable for all sample types.
Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics to fight infectious disease.
Set up experiments in minutes and get results in less than 24 hours to rapidly advance knowledge about emerging infectious disease.
Using this panel you can also identify and validate biomarkers for disease severity and evaluate the effect of vaccines & therapies
GeoMx DSP COVID-19 Protein and RNA Analysis
Rapidly perform high-plex spatial analyses of the host response in FFPE or fresh frozen tissue using the GeoMx Digital Spatial Profiler (DSP). NanoString’s GeoMx DSP platform enables high-plex protein and RNA experiments in key areas of biology such as molecular response, cellular (immune) response, tissue damage, and drivers of individual susceptibility to severe forms of disease.
The GeoMx COVID-19 Immune Response Atlas, a ~1,850-plex RNA assay, enables spatial studies of the SARS-CoV-2 virus and host response. RNA targets include COVID-19 receptors and proteases, pulmonary alveolar type I and II markers, lung biology markers, viral response markers, and SARS-CoV-2 probes. RNA targets are profiled simultaneously using the GeoMx DSP and an Illumina next-generation sequencer (NGS) for readout. Users can run ACD RNAscope™ probes alongside GeoMx RNA probes to identify regions of interest.
A five-antibody custom, ready-to-go protein panel, with receptor, protease, and viral markers is available through the GeoMx Technology Access Program or for order through Abcam. This COVID-19 GeoMx-formatted Antibody is run with the 20-plex GeoMx Immune Cell Profiling Core (plus controls) with readout on the nCounter Analysis System. Users can add up to six 10-plex modules including the Immune Activation Status, Immune Cell Typing, and/or Cell Death modules to more deeply profile proteins involved in T cell activation and cell death. NanoString scientists can recommend commercially-available markers for lung epithelium, nasal epithelium, immune response markers, and the viral spike protein.
Insights to Gene Profiling
Profile 785 human or mouse genes across 50+ pathways
Study elements of host response in human and mouse
Study the five elements of the host response in human and mouse: (i) Host Susceptibility (ii) Interferon Response (iii) Innate Immune Cell Activation (iv) Adaptive Immune Response (v)Homeostasis
Determine pathogen presence
Detect the presence of a pathogen and evaluate organ-specific tissue damage with a Panel Plus spike-in
Quantify the presence and relative abundance of 14 different immune cell types
Developed for understanding the complexities of the immune response to infectious disease, including COVID-19.
The eight essential components of stem cell biology
Stem Cell Renewal:
Stem Cell Prolifiration
PSC Pluripotency Markers and Regulators
Naive State/Primed State
Histone Acetylation & Methylation
Oxidative Stress Response
Amino Acid Metabolism
Fatty Acid Metabolism
Differentiation Signaling and Pathways:
HOX Gene Activation
Endodermal /Ectodermal /Mesodermal Lineage Markers
Key Somatic Cell Types
Custom & Clinical Products
Daily Sample Throughput
Self-assembled, interchangeable probes, optimized for smaller validation projects with maximum flexibility
Self-assembled, interchangeable probes for high-throughput, sample multiplexing projects
User-designed, turn-key solution that comes ready-to-use
mRNA, CNV, Fusions
mRNA, miRNA, CNV, Fusions
Cell line drug screen, biomarker development, infectious disease
Gene Signature Development
Model Organism, Microbes, Agriculture
nCounter Human Host Response Panel includes 785 genes; 12 internal reference genes for data normalization
nCounter Mouse Host Response Panel includes 785 genes; 12 internal reference genes for data normalization
Coronavirus Panel Plus, 20 Probe Panel Plus. Includes 9 probes targeting the SARS-CoV-2 virus, 1 probe for the human gene encoding the viral receptor ACE2, and 10 additional probes targeting SARS and other human coronaviruses
Low RNA Input Kit, Kit for use with all Low RNA Input Primer Pools
Primer pools for the Host Response Panel (for use with the Low RNA Input Kit)
nCounter Master Kit:
Reagents, cartridges, and consumables necessary for sample processing on nCounter MAX and FLEX Systems
nCounter Sprint Cartridge:
Sample Cartridge for nCounter SPRINT System
nCounter SPRINT Reagent Pack containing Reagents A, B, C, and Hybridization Buffer
Please contact us for more info at firstname.lastname@example.org
AUTOIMMUNE DISEASE AND CHRONIC INFLAMMATORY DISEASE COVERAGE
Chronic inflammatory disorder that impacts the lining of joints.
Chronic inflammatory of the digestive tract.
Autoimmune disease is where the immune system mistakenly attacks the insulin-producing cells of the pancreas
Demyelinating disease that disrupts communication with the nervous system.
Immune-mediated disease that causes skin cells to rapidly build up on the surface of the skin
Certain treatments and infections have been reported to interfere with the immune system and induce a series of autoimmune disease or adverse immune-related events.
Chronic inflammatory disease that manifests systematically throughout the body.
Inflammatory Bowel Disease
Type 1 Diab
Type 1 Diabetes
Systematic Lupus Erythematosus
Induced Adverse Immune Events
Immune Checkpoint Coverage
Pathways Regulating Glia
(178/180 Hs/Mm Genes)
Inflammation & Peripheral Immune Invasion
(187/188 Hs/Mm Genes)
Cell Stress & Damage Response
(127/134 Hs/Mm Genes)
NO Metabolism and Signaling
Oxidative & Nitrosative Stress
MAPK & PI3K
Antigen Processing & Presentation