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nCounter® Neuroinflammation Panel

nCounter® Neuroinflammation Panel

Prosigna Score / ROR Score:

The ROR Score has been validated to predict the risk of recurrence of disease in ER+ breast cancer after surgery and treatment with 5 years of endocrine therapy. The ROR score depends upon the biology of the intrinsic subtypes, the proliferation score of the tumor, and the tumor size as shown in the equation below:

ROR = aRLumA + bRLumB + cRHer2 + dRBasal + eP + fT

Each of the R variables in the equation above indicate the Pearson correlation coefficient of the PAM50 expression profile for the tumor compared to each of the prototypical centroids for the intrinsic subtypes shown in the heatmap below. P is the proliferation score, which is the average gene expression profile of genes associated with cell-cycle progression and T is the tumor stage.

Figure: Heatmap of PAM50 genes by subtype. Red is higher expression and green is lower expression

nCounter® Neuroinflammation Panel

Neuroinflammation research today requires a broad view of all the underlying aspects of neurological disorders and injury, including an assessment of neurotransmission, neuron-glia interactions, neuroplasticity, cell integrity, neuroinflammation, and metabolism.


The nCounter Neuroinflammation Panels support and simplify your neuroinflammation research needs by providing a complete view of the complex interplay between the immune system and the Central Nervous System (CNS).


These panels deliver a comprehensive evaluation of the pathways, processes, and cell types that are involved in neuroinflammation like :

  • Gene expression profiling of neuroimmune interactions

  • The study of drug treatment response and signature generation

  • Biomarker characterization

  • Research of neurodegenerative disease, traumatic brain injury, psychiatric disorders, neuropathic pain, CNS infection, and others

GeoMx DSP COVID-19 Protein and RNA Analysis

  • Rapidly perform high-plex spatial analyses of the host response in FFPE or fresh frozen tissue using the  GeoMx Digital Spatial Profiler (DSP). NanoString’s GeoMx DSP platform enables high-plex protein and RNA experiments in key areas of biology such as molecular response, cellular (immune) response, tissue damage, and drivers of individual susceptibility to severe forms of disease.

  • The GeoMx COVID-19 Immune Response Atlas, a ~1,850-plex RNA assay, enables spatial studies of the SARS-CoV-2 virus and host response. RNA targets include COVID-19 receptors and proteases, pulmonary alveolar type I and II markers, lung biology markers, viral response markers, and SARS-CoV-2 probes. RNA targets are profiled simultaneously using the GeoMx DSP and an Illumina next-generation sequencer (NGS) for readout. Users can run ACD RNAscope™ probes alongside GeoMx RNA probes to identify regions of interest.

  • A five-antibody custom, ready-to-go protein panel, with receptor, protease, and viral markers is available through the GeoMx Technology Access Program or for order through Abcam. This  COVID-19 GeoMx-formatted Antibody  is run with the 20-plex GeoMx Immune Cell Profiling Core (plus controls) with readout on the nCounter Analysis System. Users can add up to six 10-plex modules including the Immune Activation Status, Immune Cell Typing, and/or Cell Death modules to more deeply profile proteins involved in T cell activation and cell death. NanoString scientists can recommend commercially-available markers for lung epithelium, nasal epithelium, immune response markers, and the viral spike protein.

Comprehensive

Comprehensive assessment of 23 neuroinflammation pathways and processes

Unique Cell Profiling

Unique cell typing analysis feature measures the relative abundance of 19 CNS and peripheral immune cells

Customizable

Customizable with Panel Plus option – add up to 30 genes of your choosing

Easy Workflow

nCounter workflow is streamlined, user-friendly, and efficient with just 15 minutes total hands-on time

A complete view of the complex interplay between the immune system and the Central Nervous System (CNS) with our 770 gene multiplex panel.

The eight essential components of stem cell biology

Stemness
Pluripotency
Regulatory Signaling
Epigenetics
Mechano-Signaling
Metabolism
Differentiation Signaling
Lineage Specification

Stem Cell Renewal:

  • Stem Cell Prolifiration

  • Cell Cycle

  • Senescence/Quiescence

  • Autophagy

  • Apoptosis

  • Anti-Apoptosis

  • PSC Pluripotency Markers and Regulators

  • Naive State/Primed State

Regulatory Pathways:​

  • Wnt/B-catenin Pathway

  • Hedgehog Signaling

  • AP-1 Signaling

  • PI3K-AKTmTOR Pathway

  • MAPK Pathway

  • JAK/STAT Pathway

  • Notch Signaling

Epigenetic Mechanism:

  • DNA Methylation

  • Histone Acetylation & Methylation

Mechano-Signaling:

  • Rho/ROCK Signaling

  • integrin/Cadherin Signaling

  • Hippo Pathway

Metabolism:

  • Oxidative Stress Response

  • Hypoxia Response

  • Amino Acid Metabolism

  • Fatty Acid Metabolism

  • Glutamine Metabolism

  • Glucose Metabolism

Differentiation Signaling and Pathways:

  • TGFB Signaling

  • Cytoskeletal Reorganization

  • MET/EMT Signaling

  • HOX Gene Activation

Differentiation Lineage:

  • Endodermal /Ectodermal /Mesodermal Lineage Markers

  • Key Somatic Cell Types

Custom & Clinical Products

Assay Type
Product
Maximum Targets
Daily Sample Throughput
Analytes Offered
Common Applications

Custom codeSets

Elements TagSets

PlexSet Reagents

Self-assembled, interchangeable probes, optimized for smaller validation projects with maximum flexibility

Self-assembled, interchangeable probes for high-throughput, sample multiplexing projects

User-designed, turn-key solution that comes ready-to-use

216

96

800

24-96

24-96

192-1152

mRNA, CNV, Fusions

mRNA, Fusions

mRNA, miRNA, CNV, Fusions

Cell line drug screen, biomarker development, infectious disease

Gene Signature Development

Model Organism, Microbes, Agriculture

nCounter Human Neuroinflammation Panel:

Includes 770 genes, including 13 internal reference genes for data normalization

Description

12 Reactions

Pack Size

XT-CSO-HNROI1-12

SKU

nCounter Mouse Neuroinflammation Panel:

Includes 770 genes, including 13 internal reference genes for data normalization

Description

12 Reactions

Pack Size

XT-CSO-MNROI1-12

SKU

nCounter Master Kit:

Reagents, cartridges, and consumables necessary for sample processing on nCounter MAX and FLEX Systems

Description

12 Reactions

Pack Size

NAA-AKIT-012

SKU

nCounter Sprint Cartridge:

Sample Cartridge for nCounter SPRINT System

Description

12 Reactions

Pack Size

SPRINT-CAR-1.0

SKU

nCounter SPRINT Reagent Pack containing Reagents A, B, C, and Hybridization Buffer

Description

192 Reactions

Pack Size

SPRINT-REAG-KIT

SKU

Low RNA Input Kit:

48rxn kit for profiling from low sample input amounts

Description

48 Reactions

Pack Size

LOW-RNA-48

SKU

nCounter Human Neuroinflammation Primer Pool:

MTE primer pools for Low Input RNA profiling (770 genes) 757 neuroinflammation related human genes + 13 internal reference controls. Master Kit, RNA Low Input Kit, and Panel CodeSet Required

Description

12 Reactions

Pack Size

PP-HNROI1-12

SKU

nCounter Mouse Neuroinflammation Primer Pool:

MTE primer pools for Low Input RNA profiling (770 genes) 757 neuroinflammation related mouse genes + 13 internal reference controls. Master Kit, RNA Low Input Kit, and Panel CodeSet Required

Description

12 Reactions

Pack Size

PP-MNROI1-12

SKU
SKU
Description
Pack Size

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