timsTOF Series

timsTOF Series

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Screen, identify & semi-quantify Known & Unknown targets with much more confidence

Identified Polar, a nonpolar compound in a single run

>12 min Run & Analysis time (Sample to Report)

Curated Library & Methods for over 6000+ Toxicology relevant compounds & their metabolites

 

New compound can be added in few clicks

UHPLC combined with true MSn and comprehensive Drug Libraries

Bruker Daltonics the leader in Mass Spectrometry Solutions Explaining TIMS within timsTOF Technology

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Protein Interaction Network
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An instrument for every need:

Integrated benchtop system for Research Labs

For Core Labs and High Sample Throughput

nCounter Life Science Assays:

nCounter Elements™:

Expandable with Additional Prep Station:

Enterprise Package:

PROSIGNA optional add-on:

Runs Per Day:

Throughput (Lanes Per Day):

Hands on Time:

Reaction Volume Required:

Linear Dynamic Range:

Throughput:

Yes

Yes

No

No

No

2

24

10 mins

Up to 35 µl

6 x10* total count

12 lanes/6 hours

Yes

Yes

Yes

Yes

No

4*

48-96*

15 mins

Up to 30 µl

7 x10* total count

12 lanes/2.5 hours

nCounter Sprint
nCounter Flex

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timsTOF

Assays/Consumables/Software

Trapped Ion Mobility Spectrometry (TIMS) is a separation technique in the gas phase, which resolves sample complexity with an added dimension of separation in addition to HPLC and mass spectrometry, increasing peak capacity and confidence in the compound characterization. TIMS device also serves to accumulate and concentrate ions of a given mass and mobility, enabling a unique increase in sensitivity and speed along with the additional dimension of separation.


timsTOFTechnology

In this technique, ions are propelled through the TIMS tunnel by a gas flow. An electrical field controls each ion from moving beyond a position defined by the ion’s mobility, where the push it experiences from the gas flow matches the force of the electrical field. Ramping down the electrical field allows selectively releasing ions from the TIMS tunnel according to their mobility. By incorporating a TIMS device at the front of a quadrupole time-of-flight (QTOF) mass spectrometer, ions can be accumulated for a specific amount of time before being released for MS analysis.

Using the PASEF® method, peptide ions are separated using TIMS, eluted (~ 100 ms), and detected in the QTOF, generating the TIMS MS heat map. In the PASEF® method, the same TIMS separation is used with the quadrupole isolating a certain ion species during its elution and immediately shifting to the next precursor. Parent and fragment spectra are aligned by mobility values. With PASEF® technology >100 Hz sequencing speed can be achieved, and the MS/MS spectra quality of low abundant peptides can be increased by selecting them several times.

timsTOF Series
timsTOF Series

timsTOF Series

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